Pengyi technology | nano sand mill helps drug nanization to improve efficacy and safety

For the high-end market requiring excellence, such as MLCC raw materials, pharmaceutical nano preparations, etc., the sand mill only meets the "qualified" standard is far from enough to meet the demand
In order to meet the needs of the high-end market, the sand mill must have higher performance and better performance.

Nanomedicine refers to nanoparticles made directly from raw materials of drugs, or to polymer nanoparticles, nanospheres, nanocapsules, etc., as carriers, and drugs are combined together in a certain way to make drugs, with a particle size between 100 and 500 nm. Nanomedicine has many advantages, such as good stability, little irritation to gastrointestinal tract, little side effects, high bioavailability, targeting and slow release function, etc., which has been the focus of research in various countries.

 Nanomedicine has overcome some defects and insoluble problems of traditional drugs, and has made some achievements in the field of drug preparation research. Nanosuspensions are considered to be widely used to improve the dissolution of insoluble drugs.

There are many preparation methods of nanomedical drugs, including mechanical grinding, media grinding, vapor deposition and other physical preparation technology, as well as liquid phase reaction, vapor deposition and other chemical preparation technology. The medium grinding method is divided into wet grinding and dry grinding, and wet grinding is better than dry grinding, because it can obtain nanocrystals more effectively. At present, most products on the market are prepared using a sanding mechanism.

Because the traditional equipment for drug micronization cannot be used for the preparation of nanomedicine, such as colloid mill or air mill. The particle size of the drug powder obtained by the air flow grinding mechanism is generally 0.1-20 μm, of which only a small part is nanoscale. However, after grinding with a sander for a sufficient time, nanosuspensions can be prepared.

Pengyi intelligent nano sand mill mainly uses friction, shear, collision as an effective way of grinding, is currently applicable material particle size is the most extensive, the most advanced, the highest grinding efficiency of one of the grinding equipment, the largest energy density per unit volume, combined with high-quality cooling system and automatic control system, can complete the continuous grinding and continuous discharge of slurry. Greatly improve the production efficiency of the sand mill. Pengyi intelligent nano sand mill has the following core advantages. 

1. High energy density rod and pin type sand mill, narrow product particle distribution, high grinding efficiency.

2. The operating system is newly upgraded, and the flow can be set on the PLC, which is more accurate and stable.

3. Easy to operate and process control, unit energy consumption can be reduced by 10%-15%.

4. The optimized design is specially designed for the small grinding medium, so that the sand mill can better adapt to the needs of the small

5. grinding medium, improve the grinding efficiency and product quality.

6. Upgraded rod and pin grinding structure, power foot, high speed, stable operation, long life, easy to clean.

7. Fully enclosed cavity design: inert gas protection can be used to form an oxygen-free closed grinding system to avoid powder oxidation. This design allows the sander to better protect the grinding medium and product from oxygen, thereby improving the quality and stability of the product.

The grinding experiment data showed that the longer the grinding time, the more uniform the dispersion of drug particles in suspension, the smaller the drug particle size. It was found that the rapid reduction of drug particle size in the initial stage can be attributed to the presence of more cracks and crystal defects in larger drug particles, which are relatively easy to fracture and break. With the gradual increase of time, the particle size of the drug continued to decline but the decreasing speed became significantly slower until the particle size of the drug reached a stable state.

Pengyi intelligent sand mill is widely used in the pharmaceutical field because it can control the particle size well, and has the advantages of small environmental pollution, simple equipment structure and easy maintenance.